Inositol: Myo-Inositol, Chiro-Inositol or both?

Studies of myo-inositol and PCOS

The effects of myo-inositol on women with PCOS have been subject in a number of published clinical studies.

• A study published 2014 from Italian researchers concludes “MYO administration positively modulates insulin sensitivity in non-obese PCOS patients without compensatory hyperinsulinemia, improving hormonal parameters. The presence of bromelin in the formulation modulated the pro-inflammatory state that characterizes PCOS, independently of BMI.“^[1]Genazzani AD1, Santagni S, Ricchieri F, Campedelli A, Rattighieri E, Chierchia E, Marini G, Despini G, Prati A, Simoncini T.; “Myo-inositol modulates insulin and luteinizing hormone secretion … Continue reading
• In another study from 2015, myo-inositol combined with alpha-lipoic acid was tested on women with PCOS undergoing an IVF treatment. The author´s conclusion: “Our preliminary data suggest that the supplementation of myo-inositol and α-lipoic acid in PCOS patients undergoing an IVF cycle can help to improve their reproductive outcome and also their metabolic profiles, opening potential for their use in long-term prevention of PCOS.“.^[2]Rago R1, Marcucci I, Leto G, Caponecchia L, Salacone P, Bonanni P, Fiori C, Sorrenti G, Sebastianelli A.; “Effect of myo-inositol and alpha-lipoic acid on oocyte quality in polycystic ovary … Continue reading
• The number of ocytes was increased following the intake of myo-inositol and folic acid. The authors write “These data show that in patients with PCOS, treatment with myo-inositol and folic acid, but not folic acid alone, reduces germinal vesicles and degenerated oocytes at ovum pick-up without compromising total number of retrieved oocytes. This approach, reducing E(2) levels at hGC administration, could be adopted to decrease the risk of hyperstimulation in such patients.“^[3]Papaleo E1, Unfer V, Baillargeon JP, Fusi F, Occhi F, De Santis L.; “Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized … Continue reading
• A meta-study is a study that analyses a larger number of similar studies, in order to find out how robust results are. The researchers from a 2012 meta-study confirm “Among the insulin-sensitizing compounds, there is myo-inosiol (MYO). Previous studies have demonstrated that MYO is capable of restoring spontaneous ovarian activity, and consequently fertility, in most patients with PCOS.”^[4]Unfer V1, Carlomagno G, Dante G, Facchinetti F.;”Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.”;Gynecol Endocrinol. 2012 … Continue reading.

Studies of chiro-inositol and PCOS

d-chiro-inositol was also the subject of a number of clinical studies, and the effect on ovulation of women with PCOS was confirmed:

• A study from 2015 confirms the effect of chiro-inositol “D-Chiro-Inositol is effective in improving ovarian function and metabolism of patients affected by PCOS.”^[5]Laganà AS1, Barbaro L, Pizzo A.; “Evaluation of ovarian function and metabolic factors in women affected by polycystic ovary syndrome after treatment with D-Chiro-Inositol”;Arch Gynecol … Continue reading

Myo-inositol or chiro-inositol for PCOS, what is better?

Since both forms of inositol have been reviewed quite intensively for the same application, some researchers went one step beyond this and asked the question: what is better, my-inotol or chiro-inositol for women with PCOS?

The main finding seems to be: both forms are effective and have different effects. This is what researchers write:

• A study from 2014 Pizzo A., et al. “Comparison between effects of myo-inositol and D-chiro-inositol on ovarian function and metabolic factors in women with PCOS” ^[6]Pizzo A1, Laganà AS, Barbaro L. “Comparison between effects of myo-inositol and D-chiro-inositol on ovarian function and metabolic factors in women with PCOS”; Gynecol Endocrinol. 2014 … Continue reading concluded: “Both the isoforms of inositol were effective in improving ovarian function and metabolism in patients with PCOS, although myo-inositol showed the most marked effect on the metabolic profile, whereas D-chiro-inositol reduced hyperandrogenism better.“
• In a study from 2015, the authors conclude similarily “Definitely, we assumed that both treatments with myo-inositol and with D-chiro inositol could be proposed as a potential valid therapeutic approach for the treatment of patients with PCOS“^[7]Formuso C1, Stracquadanio M, Ciotta L.;”Myo-inositol vs. D-chiro inositol in PCOS treatment”; Minerva Ginecol. 2015 Aug;67(4):321-5. Epub 2015 Feb 11.
• Another study from 2012 analysed the combined application of myo-inositol and chiro-inositol and recommends “The combined administration of MI and DCI in physiological plasma ratio (40:1) should be considered as the first line approach in PCOS overweight patients, being able to reduce the metabolic and clinical alteration of PCOS and, therefore, reduce the risk of metabolic syndrome.“^[8]Nordio M1, Proietti E.; “The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation … Continue reading